SAS-PEG-SAS

Description

SAS-PEG-SAS -Succinimidyl-Amido-Succinate–Poly(ethylene glycol)–Succinimidyl-Amido-Succinate is a bifunctional PEG product with the same functional group at either end of the PEG chain.  This product is commonly used in bioconjugation and materials science.

• PEG (Polyethylene Glycol):
  • Polyethylene glycol (PEG) is water soluble because of its hydrophilic nature, resulting from the presence of numerous ether linkages in its polymer chain.
  • PEG is used due to its biocompatibility and low toxicity.  
  • It is used to modify proteins, drugs, and other molecules to improve their properties, such as increasing their circulation time in the body.
  • PEG is also soluble in various polar organic solvents, such as alcohols and acetone.
• SAS (Succinamide Succinimidyl ester):
  • The SAS (succinamide succinimidyl ester) functional groups are reactive with amines and generally retains the good water solubility characteristic of PEG
  • The succinimidyl part refers to N-hydroxysuccinimide (NHS) esters which is commonly used for bioconjugation.  
  • The presence of the SAS groups will alter the overall properties of the PEG molecule, and could alter solubility in some non-polar solvents.
  • NHS esters are used to form stable amide bonds with amine groups on proteins, peptides, and other biomolecules together.  
  • The Amido part means that there is an amide bond present.
  •  
• Factors Affecting Solubility:
  • Molecular Weight: The MW of the PEG chain can influence its solubility. Shorter PEG chains tend to be more soluble than longer chains.
  • Solvent Polarity: The solubility of SAS-PEG-SAS will depend on the polarity of the solvent. It will be most soluble in polar solvents like water.
  • Temperature: Temperature can affect solubility, generally increasing it in most solvents.

Key Applications:

• Bioconjugation:
  • This can be used to create drug delivery systems, diagnostic tools, and other biomedical devices.
  • Modifying surfaces for cell culture and other biological applications.
• Hydrogel Formation:
  • It can be used to create hydrogels, which are water-absorbing polymers that have applications in tissue engineering and drug delivery.
• Surface Modification:
  • Useful in modifying the surfaces of materials to improve their biocompatibility or to attach other molecules.
• Drug delivery:
  • Creating PEGylated drug carriers to improve drug pharmacokinetics.

Polar Organic Solvents:

• These are organic liquids that exhibit a significant dipole moment due to the uneven distribution of electrons.  
• They are effective at dissolving polar solutes, such as ionic compounds and other polar organic molecules.:
  • Polar protic solvents:
    • These contain hydrogen atoms bonded to electronegative atoms (like oxygen or nitrogen), allowing them to form hydrogen bonds.  
    • Examples: water, methanol, ethanol.  
  • Polar aprotic solvents:
    • These are polar but lack hydrogen atoms that can participate in hydrogen bonding.  
    • Examples: acetone, dimethylformamide (DMF), dimethyl sulfoxide (DMSO).