SVA-PEG-SVA

Description

SVA-PEG-SVA: Succinimidyl Valerate Polyethylene Glycol Succinimidyl Valerate is characterized by a succinimidyl valerate (SVA) ester group at both end of the PEG chain. The succinimidyl valerate is an active ester used for the PEGylation of primary amines. The reaction of the SVA with an amine forms a stable amide linkage. This reaction may be performed in an organic solution with a base catalyst or may be performed in an aqueous solution at a pH range of 8 to 9. The reaction should be allowed to mix for a minimum of 4 hours. By tailoring the pH of a reaction, the selectivity for the PEGylation of a specific site is increased.

Hydrolysis half-lives at pH 8, 25 °C     Half-life (minutes)33.6

Key Properties and Uses:

• Bifunctionality: The SVA ester can react with primary amines on proteins, peptides, or other molecules to form stable amide bonds. This property makes PEG-SVA a valuable tool for modifying and conjugating various biomolecules.  
• Water Solubility: PEG’s hydrophilic nature imparts excellent water solubility to PEG-SVA, making it compatible with aqueous environments.
• Biocompatibility: PEG is generally considered biocompatible, reducing the risk of immune responses or toxicity when used in biological applications.  
• Applications:
  • Protein Modification: PEGylation of proteins using PEG-SVA can enhance their solubility, stability, and half-life, making them suitable for therapeutic and diagnostic purposes.
  • Drug Delivery: PEG-SVA can be used to conjugate drugs or nanoparticles, improving their circulation time and targeting to specific tissues.
  • Biomaterials: PEG-SVA can be incorporated into biomaterials to modify their surface properties and interactions with biological systems.
  • Diagnostics: PEG-SVA can be used for labeling and detection of biomolecules in various diagnostic assays.

When using PEG-SVA, it is important to consider factors such as reaction conditions (pH, temperature, concentration), purification methods, and potential side reactions. Proper handling and storage are also crucial to maintain the product’s quality and reactivity.