mPEG-OPSS

Description

mPEG-OPSS, is a polyethylene glycol (PEG) product with an orthopyridyl disulfide (OPSS) functional group at one end of the PEG chain and a methoxy at the other end.

Key features and benefits:

• Thiol-reactive OPSS group: The OPSS group reacts specifically with thiol groups, forming a stable disulfide bond. This reaction is mild and does not require harsh conditions, making it suitable for sensitive biomolecules.

•    Reversible bond formation: Creates a disulfide bond that can be cleaved under reducing conditions allowing for the release of the thiol group and subsequent conjugation to other molecules

• Versatile applications: mPEG-OPSS finds applications in various fields, including:
• Bioconjugation: Modifying proteins, peptides, and antibodies to enhance their properties, such as stability, solubility, and bioavailability.

• Nanoparticle functionalization: Attaching targeting ligands or therapeutic agents to nanoparticles for drug delivery and imaging. Modification of nanoparticles with PEG to improve biocompatibility and stability.  
• Polymer chemistry: Creating functional polymers with tailored properties for materials science and biomedical engineering..  

Common applications of mPEG-OPSS:

• Protein modification: PEGylation of proteins to enhance their properties.
• Drug delivery: Development of targeted drug delivery systems.  

• Protein modification: Can be used to modify proteins with PEG, increasing their solubility, stability, and reducing immunogenicity.  
• Nanoparticle functionalization: mPEG-OPSS can be used to attach PEG to nanoparticles, improving their biocompatibility and circulation time.  
• Drug delivery: Can be used to modify drug molecules with PEG, increasing their solubility and bioavailability.
• Biomaterials: mPEG-OPSS can be used to create PEGylated biomaterials with improved properties.

Soluble in:

• Water and aqueous buffers  
• Chloroform, Methylene chloride, DMF (Dimethylformamide), DMSO (Dimethyl sulfoxide)

Less soluble in:  Alcohol, Toluene

Insoluble in: Ether

Molecular weight of PEG: Higher molecular weight PEG chains tend to be more water-soluble.