mPEG-NH2

Description

.mPEG-NH2: Methoxy Poly(ethylene glycol) Amine, is a PEG product with a reactive primary amine (NH2) group on one end of the PEG chain and a methoxy group on the other end. This functional group enables efficient conjugation with various molecules, including proteins, peptides, drugs, and nanoparticles. 

Benefits of Using:

• Enhanced Stability: The formation of amide bonds with activated carboxylic acids (e.g., NHS esters) to form stable amide bonds, improving the stability and shelf life of the modified molecules.
• Protects conjugated molecules from degradation, enzymatic cleavage and clearance.    
• Undergoes reductive amination with aldehydes or ketones to form stable imine bonds.
• Improved Solubility: Increases solubility of hydrophobic molecules.
• Targeted Delivery: Enables targeted delivery of drugs and nanoparticles.
• Prolonged Circulation Time: Extends the duration of therapeutic effects.

Key Features and Benefits:

• Wide Range of Applications:
  • Bioconjugation: Modifying proteins, peptides, and other biomolecules for research and therapeutic purposes reducing immunogenicity, and improves solubility
  • Nanotechnology: Modifying nanoparticles for target specific cells or tissues and imaging.
  • Surface Modification: Creating biocompatible and non-fouling surfaces for medical devices and biosensors.
  • Biosensor Development: Improve sensitivity and specificity.

Solubility

• Water: highly soluble in water   
• Methanol,  Ethanol,  THF (Tetrahydrofuran  soluble in
• Dichloromethane: While less common, can also be dissolved in dichloromethane.  

The solubility of mPEG-amine can be influenced by the molecular weight of the PEG chain. Higher molecular weight PEG chains tend to increase the water solubility of the compound.