mPEG-HZ

Description

mPEG-Hydrazide is a monofunctional polyethylene glycol (PEG) derivative that features a hydrazide functional group at one end of the PEG chain and a methoxy group at the other end. This reactive group allows for efficient conjugation with aldehydes and ketones.

• Reactivity: The hydrazide group readily reacts with aldehydes and ketones under mild conditions to form hydrazones.
• Solubility: PEG-hydrazide is generally soluble in water, aqueous buffers, and organic solvents, providing flexibility in reaction conditions.
• Applications:
  • Protein conjugation: Attaching PEG to proteins to improve solubility, stability, and reduce immunogenicity.
  • Peptide modification: Conjugating peptides to surfaces or carriers for various biomedical applications.
  • Drug delivery: Encapsulating or conjugating drugs to improve bioavailability and reduce toxicity.
  • Bioconjugation: Creating bioconjugates with other molecules containing aldehydes or ketones, such as carbohydrates, nucleic acids, and small molecules.