mPEG-EPOX

Description

mPEG-Epoxide is a linear monofunctional PEG derivative with epoxide, epoxy or glycidyl ether functionality. Epoxide is a valuable reagent in the field of bioconjugation. The reactive epoxide group allows for efficient coupling with molecules containing amine or hydroxyl groups, making it suitable for modifying proteins, peptides, and other biomolecules

Key Properties and Applications:

Reactivity: The epoxide group readily reacts with amine groups under mildly alkaline conditions (pH 8.0-9.5).

Solubility: Epoxide-PEG is soluble in both aqueous and organic solvents, providing flexibility in reaction conditions.

Applications:

Protein modification: Improving solubility, stability, and reducing immunogenicity of proteins.

Peptide conjugation: Attaching peptides to surfaces or carriers for various biomedical applications.

Surface modification: Creating biocompatible and antifouling surfaces for medical biosensors and other materials.

Drug delivery: Encapsulating or conjugating drugs to improve bioavailability and reduce toxicity.

Solubility: Soluble in water, aqueous buffers, chloroform, methylene chloride, DMF, DMSO, and less soluble in alcohol and toluene.