MAL-PEG-SVA

MAL-PEG-SVA

$195.00 – $1,300.00

Maleimide-PEG-Succinimidyl Valarate (MAL-PEG-SVA) is available in molecular weights of 2,000, 3,400 and 5,000.

Packaged in 100 mg, 500 mg, 1 gram, and 5 gram bottles.

Shipping charges will be calculated based on the total order.

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Description

Maleimide-PEG-SVA (Succinimidyl Valerate) is a heterobifunctional combining a maleimide group at one end of the PEG chain and a succinimidyl valerate group at the other. This unique structure allows it to react with both thiol (-SH) and amine (-NH2) groups, making it highly versatile for various bioconjugation applications.  

Key Features:.

  • Polyethylene Glycol (PEG) Spacer: Provides hydrophilic properties, enhancing water solubility and reducing immunogenicity.
  • Succinimidyl Valerate (SVA) Group: Reacts with primary amines to form stable amide bonds.  
  • Maleimide Group: Reacts with thiols to form stable thioether bonds.

Applications:

  • Protein-protein conjugation: Crosslinking proteins with specific thiol and amine groups.
  • Protein-drug conjugation: Attaching drugs to proteins for targeted delivery.
  • Antibody-drug conjugates: Connecting therapeutic agents to antibodies for cancer treatment.
  • Bioconjugation of biomolecules: Modifying enzymes, peptides, and nucleic acids with various functional groups.  
  • Nanomaterial functionalization: Attaching biomolecules to nanoparticles for biomedical applications.  

Advantages:

  • High reactivity: Reacts with both thiol and amine groups under mild conditions.
  • Water solubility: The PEG spacer improves water solubility, enhancing biocompatibility.
  • Stability: The formed thioether and amide bonds are stable, ensuring long-lasting conjugation.

 

Additional information

Molecular Weight

2000, 3400, 5000
Bottle Size

100 mg, 500 mg, 1 gram, 5 gram

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