Frequently Asked Questions
What are the storage conditions for the products?
Because PEG reagents are temperature, light, and moisture sensitive they should be stored in a -15C freezer upon receipt. Please allow PEG reagents to equal room temperature prior to opening. We recommend storing our PEG reagents as the dry, powder form only and not in any type of solution. Each time the bottle is opened it will need to be backfilled with an inert gas (i.e. Argon, Nitrogen) before it is stored again.
If your reagent requires rebottling please follow these steps:
Allow reagent to equilibrate to room temperature
While reagent is thawing prepare glove box or another suitable area for packaging which will allow for an inert atmosphere
Flush the repackaging enclosure with an inert gas (i.e. Argon, Nitrogen)
Repackage into desire aliquots
Flush each aliquot with inert gas before closing
Store each aliquot at or below -15C until ready to use
How do I place an order?
You can place an order on our products page at www.laysanbio.com/products or by clicking on the products link in the menu. You can also fax your order to us at 256-586-9007. We need a billing address, shipping address, delivery telephone number, e-mail address, item information, and a P.O. number or credit card information. We accept VISA or MasterCard. Please contact us at info@laysanbio.com or at 1-888-8LAYSAN (888-852-9726) with any questions.
How do you ship your reagents?
We ship all of our reagents at room temperature for overnight delivery in the United States. Most international shipments arrive within 3-4 days.
How do I get the structures for your products?
If there is not a structure posted for the reagent you are interested in, please contact us at info@laysanbio.com for structure information.
How do I get an MSDS?
An MSDS will be sent with your shipment. If you need one beforehand, please contact us at info@laysanbio.com to request an MSDS.
What is the difference between your ester reagents, SC and SCM?
SCM
Hydrolysis half-life is 0.75(minutes) at pH8, 25°C
Amide linkage
Faster conversion
Good conversion in organic; not good in aqueous
SC
Hydrolysis half-life is 20.4(minutes) at pH8, 25°C
Urethane or Carbamate linkage
Longer reaction time
Slower hydrolysis
Good in organic; also works in aqueous
Do you have more information on your new SVA reagents?
Click here to download more information regarding our new SVA reagents.
What is the half-life information for your ester reagents?
Click here to download information regarding the half-lives of our esters.
How do I deprotect the BOC and FMOC reagents?
Protocol to Deprotect BOC
Standard BOC Amino Acid Deprotection
50% (v/v) TFA/DCM; 50 minutes at room temperature
Follow with washings with 5% (v/v) DIPEA/DCM to remove TFA
Protocol to Deprotect FMOC
Standard FMOC Amino Acid Deprotection
Place the FMOC protected product in a round bottom flask and add 20% (v/v) piperdine in DMF(approximately 10ml/gm resin)
Shake the mixture at room temperature for 30 minutes
Filter the FMOC protected product and wash it with several portions of DMF
What is PEG's solubility?
PEG in all molecular weights are soluble at concentrations less than a 50:50 w/w concentration in water and other solvents.
PEGs are readily soluble in dichloromethane, chloroform, acetonitrile and water at room temperature.
PEGs require heat to be soluble in toluene, methanol, ethanol, and isopropanol.
PEGs are not soluble in ethers, ethylene glycol, hexane, and are not soluble in most alcohols at room temperature.
If you need an organic solvent, dichloromethane and acetonitrile are two good choices.
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